Courses Run
- B.Sc. (Honours School) three-year (Six Semesters)
course
- M.Sc. (Honours School) two-year (Four Semesters) course
- M.Sc. (Honours) two-year (Four Semesters) course
- Ph.D (Three – Five year course), One Semester course
work is compulsory.
Courses
offered/Distribution of seats
Course
Name
|
Duration
(Year)
|
System
|
Total Seats
|
Reserved
Categories
|
SC/ST
|
BC
|
RA
|
Others
|
B.Sc. (Hons. School)
|
3
|
Semester
|
40
|
10
|
2
|
3
|
5
|
M.Sc. (Hons.)
|
2
|
Semester
|
30
|
7
|
2
|
2
|
4
|
Ph.D*
|
3
– 5
|
Semester
|
50
|
14
|
3
|
3
|
5
|
*Number of
seats being offered each year for Ph.D may vary according to the vacancies
available with the faculty.
Eligibility for admission and Mode of selection of students
·
B.Sc. (Hons. School): Senior Secondary
(10+2) examination in any science subject (any combination) with at least 50%
marks in the aggregate, or any other examination recognized as equivalent
thereto by Guru Nanak Dev University, Amritsar.
Admission will be based on merit of the
candidate in the qualifying examination.
·
M.Sc. (Hons. School): B.Sc. (Hons. School) degree in Human Genetics from Guru Nanak Dev University
with at least 50% marks in aggregate or any other degree recognized as
equivalent thereto by Guru Nanak Dev University.
Admission will be based on merit of the candidates in B.Sc. (Hons. School)
Human Genetics.
·
M.Sc. (Honours): B.Sc. degree (10+2+3 system of education) in any science subject (any
combination) with at least 50% marks in aggregate from Guru Nanak Dev
University, M.B.B.S., B.D.S., or any other examination recognized equivalent
thereto by the University.
Admission will be based on merit of the candidates in Entrance Test conducted by the Department.
·
Ph.D :
Candidates with a Master Degree in Human Genetics or allied subject with 55%
marks (50% for SC/ST).
Admission
to Ph.D degree course will be made through an eligibility test to be conducted
by the University. The qualifying candidates will also be eligible for
fellowships offered by the University. Exemptions :(i) UGC/CSIR-J.R.F., N.E.T. or Equivalent qualified candidates. (ii) Approved
teachers of University and colleges before the implementation of N.E.T.
Fee Structure of each course
- Approx. Rs. 23,000-00 for B.Sc.
(Honours School) Part-I (Semester-I/II)
- Approx. Rs. 25,000-00 for
M.Sc. (Honours) Part-I (Semester-I/II)
Major Equipment in the Department
Automatic
DNA Sequencer (ABI PRISM 377), Automatic pipetter, Analytical Balances,
Automatic Ice Flaker, Automatic Photomicrographic System, Bionocular
Microscopes, Body Fat Analyser, Cold Centrifuge, CO2 incubators, Cold Room,
ELISA Reader, Fluoroscent Microscope, Freezers, Hydridization Incubator,
Inverted Microscope, Semi-Automatic Blood Analyser, Stereo Microscope, Thermal
Cyclers, Vertical and Horizontal, Laminar Flow, Vertical PAGE apparatus, Water
Purification Systems, Nucleic acid synthesizer, Manual sequencers,
Hybridization Incubator, 2-D gel Electrophoresis system, Liquid Scintillation
Counter, Gel Documentation System, Lyophiliser, Gene Pulsar, Pulse-field Gel
Electrophoretic System.
Research Activities and
Special Contributions of the Department
The department
of Human Genetics was established in 1988 as part of School of Life Sciences
under specific recommendations of the UGC. The discipline of Human Biology and
Human Genetics came into existence as a separate department in 1990. It was
renamed as the Department of Human Genetics in 1993. The Centre for Genetic Disorders was set up in the department
in 1990 under a grant of Rs 1.57 Crores sanctioned to Prof. Dr Jai Rup Singh by
the Department of Biotechnology, Govt. of India. As per the undertaking given
to Govt. of India, the Guru Nanak Dev University took over the Centre after 5
years. The center for Genetic Disorders was merged with the Department of Human
Genetics w.e.f April 1, 2010. Since its inception, the centre has been
providing diagnostic services to cases suspected of chromosomal anomalies and
guidance regarding future options to patients and families with genetic
diseases. The clinical diagnostic and genetic counseling facilities at Centre
for Genetic Disorders include ultrasound, ERG-VEP equipment, complete minor
O.T. facilities, London Dysmorphology Data Base and Photo Library, London
Neurogenetic Data Base, Mendelian Inheritance in Man, METAGENE (Data Base of
Inborn Errors of Metabolism).
The
research activities of the department pertain to molecular genetics,
cytogenetics, growth and population studies. A
multi-tier approach is underway for the comprehensive screening and evaluation
of the spectrum of genetic diseases prevalent in the population groups of the
northwest region of India. Genetic epidemiological surveys precede growth,
cytogenetic and molecular investigations. Some databases for different genetic
diseases have been set up and are being extended in view of genetic variations
among the people inhabiting this region. The population and growth studies
conducted on different populations of Punjab have provided important
information about nutritional and anthropometric profiles of various caste
groups. The database for various body morphological characteristics and body
composition parameters of these populations has also been set up. The molecular
genetic profile of various diseases, viz. cardiovascular diseases,
hypertension, obesity, diabetes, eye disorders, cancer etc., is being
investigated to evaluate the genetic susceptibility or resistance, if any, of
certain individuals towards these diseases. A microsatellite laboratory for gene mapping studies
established by Centre for Genetic Disorders is involved in mapping of genes in
large families suffering from various genetic diseases. Research related to
identification of genes causing various types of eye disorders is being
undertaken. By positional cloning, mapping of the genes for some novel
phenotypes of congenital cataract on chromosomes; 1, 3, 13, 14, 15, 16, 19, 21,
and 22 has been successful. A novel locus and a novel gene for night blindness
in an autosomal recessive night blindness family have been identified. Novel
mutations in EXT1 & EXT2 genes linked and segregating with the disease
phenotypes have been identified in autosomal dominant hereditary multiple
exostoses (HME) families of Indian origin by linkage and mutation analyses.
A
rich collection of data and samples from patients suffering from different
genetic disorders and also from various population groups is being maintained
at department. The repository of Center for Genetic
Disorders has blood/DNA/lens samples from cases suffering from various eye disorders
including congenital cataract, retinitis pigmentosa, Marfan's syndrome,
familial myopia, Diabetic Retinopathy, Glaucoma and other ocular anomalies.
The
research work of the faculty has been included in International databases i.e. Online
Mendelian Inheritance in Man (OMIM), National
Centre for Bioinformatics (NCBI) database and World Health Organization (WHO) database viz.
1.
The research work of Dr.Jai Rup
Singh and Dr. Vanita Kumar in OMIM
§
"central pouch-like"
cataract with Y-sutural opacities mapped to 15q21-q22, OMIM No. : 605728.
§
sutural cataract with punctate and
cerulean opacities mapped at 22q11.2-q12.1, OMIM No. : 607133.
§
cerulean cataract mapped to a novel
locus at 16q23.1, OMIM No. : 610202. This cataract phenotype has been
classified as cerulean cataract type-4.
§
posterior polar cataract mapped to a
new locus at 14q, OMIM No. : 610634 and this phenotype is classified as
posterior polar cataract type-5
2.
The research work of Dr. Sharda
Sidhu on “Prevalence of Anaemia in Preschool Children of Punjab” has been
included in WHO database on Iron Deficiency/Anaemia.
3.
Several novel SNPs and sequences of
genes of Type-2 diabetes in NCBI gene bank as a part of the work of Dr. A.J.S
Bhanwer
4.
Gene sequences of two candidate
genes for Psoriasis have been deposited in NCBI database as part of work of Dr.
Gursatej Gandhi.
The
Department of Human Genetics in collaboration with Centre of genetic disorders
has organized five international symposia, many internationally collaborative
hands-on-training workshops and lectures by renowned scientists of national and
international repute. The department has undertaken 32 research projects since
its inception in 1990 and a total research grant of Rs. 5.6 crores has been
received. The research output of the department is reflected in the published
work which includes four books and 241 research articles in Indian and foreign
journals. The Centre for Genetic Disorders as part of the department is one of
the leading centers of India providing diagnostic and genetic counseling
services to the people of North West India. The department is a
DST-FIST-sponsored department, and a UGC-SAP recognized department.
Best Five Publications (Faculty wise)
1 |
Dr. AJS Bhanwer |
- Kaur, I., Chakrabarti, S., Sarhadi, V.K., Roy, S., Majumder, P.P., Bhanwer, A.J.S. and Singh, J.R. (2002). Genomic diversities and affinities among four endogamous groups of Punjab (India) based on autosomal and mitochondrial DNA polymorphisms. Hum. Biol. 74: 819-836.
- Rai, K., Sharma, S., Koul, A., Bhat, A.K., Bhanwer, A.J.S and Bamezai, R.N.K. (2007). Interaction between the UCP2-866G/A. mtDNA 10398G/A and PGCαр. Thr394Thr and р.Gly482Ser polymorphisms in type 2 diabetes susceptibility in North Indian population. Hum. Genet. 122: 535-540. DOI 10.1007/s00439-007-421-424 (online).
- Sharma, S., Rai, E., Bhat, A.K., Bhanwer, A.J.S. and Bamezai, R.N.K. (2007). A novel subgroup Q5 of human Y- chromosome haplogroup Q in India. BMC Evol. Biol. 7: 232.
- Badaruddoza, Bhanwer, A.J.S., Sawhney, R., Randhawa, N.K., Matharoo, K. and Barna, B. (2009). A Study of Angiotension Converting Engyme (ACE) gene polymorphism in Essential Hypertension among a Business Community in Punjab. Int. J. Hum. Genet. 9 (3-4): 231-234.
- Sharma, S., Rai, E., Sharma, P., Jena, M., Singh, S., Darvish, K., Bhat, A.K., Bhanwer, A.J.S., Tiwari, P.K. and Bamezai, R.N.K. (2009). The Indian origin of paternal haplogroup R1a1 substantiates the autochthonous origin of Brahmins and the caste system. J. Hum. Genet. Doi:10.1038/jhg.2008.2
|
2 |
Dr. Sharda Sidhu |
- Sidhu, S., Kaur, A. and Prabhjot (2005). Prevalence of overweight and obesity among urban and rural adult females of Punjab. Anthropolgischer Anzeiger 63: 341-345.
- Sidhu, S., Marwah, G. and Prabhjot (2005). Prevalence of overweight and obesity among the affluent adolescent school children of Amritsar, Punjab. Collegium Antropologicum 29: 53-55.
- Sidhu, S., Kaur, H. and Kaur, R. (2006). Overweight and obesity in affluent school children of Punjab. Annals of Human Biology 33: 255-259.
- Sidhu, S. Luthra S and Kumari K (2007). Prevalence of hypertension in adult population of Punjab. Indian Journal of Physical Anthropology of Human Genetics. 26: 63-68.
- Kapoor, M., Kapur, S., Mehra, S., Dube, U., Shard, S. and Sidhu, S. (2009). Genetic variation in D7S1875 repeat polymorphism of leptin gene is associated with increased risk for depression: a case control study from India. Depression and Anxierty. 26 (9) 791-795.
|
3 |
Dr. Gursatej Gandhi |
- Gandhi, G. and Singh, B. (2004). DNA damage in untreated and treated leprosy patients. Mutagenesis 19: 483-488.
- Gandhi, G. and Anita (2005). Genetic damage in Mobile Phone users: Some preliminary findings. Ind. J. Hum. Gen. 11: 99-104.
- Gandhi, G. (2007). A Sikh perspective on human genetic advances. Eub. J. Asian Int. Bioeth. 17: 115-119.
- Gandhi, G. and Chopra G. (2009) DNA Damage in Peripheral Blood Leukocytes of Physically Active Individuals as measured by the Alkaline Single Cell Gel Electrophoresis Assay. Environmental & Molecular Mutagenesis, 50:291-303. Online DOI 10.1002/em.20457.
- Gandhi, G. and Jeevan Jyoti (2010). Assessment of DNA damage in Peripheral Blood Leukocytes of Patients with Essential Hypertension by the Alkaline Comet Assay. Cytologia (in Press)
|
4 |
Dr. Vasuda Sambyal |
- Gupta, T., Batra, A.P.S., Sidhu, S and Sambyal, V. (2008) Association between Body mass index and esophageal cancer patients. Journal of Biotechnology 136 : S112
- Kaur, H., Singh, A.P., Singh, G., Sidhu, S., Sambyal, V. (2009). Plasma Monocyte Chemoattractant Protein-1 as risk marker in Type 2 diabetes and Coronary Artery Disease in North Indians. Diabetes and Vascular Disease Research; 6 (4): 288-290.
- Kaur, H., Kaur, G.M., Setia, N., Sudan, M., Uppal, M.S., Yamini., Batra, A.P.S., Sambyal, V. (2009). Chromosomal instability in the lymphocytes of breast cancer patients. Indian Journal of Human Genetics. 15 (1) 13-18.
- Guleria, K. and Sambyal, V. (2010). Spectrum of Chromosomal Aberrations in Peripheral Blood Lymphocytes of Gastrointestinal Tract (GIT) and Breast Cancer Patients. Int. J. Hum. Genet. 10 (1-3): 147-158.
|
5 |
Dr. Vanita Kumar |
- Vanita, V., Sperling, K., Sandhu, H.S., Sandhu, P.S., Singh, J.R. (2009). Novel EXT1 and EXT2 Mutations in Hereditary Multiple Exostoses Families of Indian Origin. Genetic Testing and Molecular Biomarkers, 13: 43-49.
- Vanita V, Daljit Singh, Peter N Robinson, Karl Sperling, Jai Rup Singh (2006) A novel mutation in the DNA binding domain of MAF at 16q23.1 associated with autosomal dominant “Cerulean Cataract” in an Indian family. Am. J. Med. Genet. 140: 558-566.
- Vanita, V., Hennies, H.C., Singh, D., Nuernberg, P., Sperling, K., Singh, J.R. (2006). Novel mutation in GJA8 associated with autosomal dominant congenital cataract in a family of Indian origin. Molecular Vision 12: 1217-1222.
- Vanita, Singh, J.R., Sarhadi, V.K., Singh, D., Reis, A., Ruschendorf, F., Follmann, J.B., Jung, M. and Sperling, K. (2001). A novel form of ‘central pouch-like cataract with sutural opacities’ maps to chromosome 15q21-22. Am. J. Hum. Genet. 68: 509-514.
- Vanita, Sarhadi, V.K., Reis, A., Jung, M., Singh, D., Sperling, K., Singh, J.R. and Buerger, J. (2001). A novel form of autosomal dominant cataract explained by gene conversion between the B-crystallin gene CRYBB2 and its pseudo-gene CRYBP1. J. Med. Genet. 38: 392-396.
|
6 |
Dr. Anupam Kaur |
- Kaur, A. and Singh, J.R. (2010). Chromosomal abnormalities: genetic disease burden in India. Int. J. Hum. Genet. 10(1-3): 1-14.
- Kaur A, Mahajan, S., Singh, J.R. (2009). Aging and Genetic Disorders: An experience with Down syndrome. Wiener Klinishe Wochenschrift-The Middle European Journal of Medicine (online): 121: 10-11.
- Kaur, A., Dhillon, S., Garg, P.D., Singh, J.R. (2008). Ring chromosome 7: In an Indian Woman. J. Intellect. Dev. Disabil. 33(1): 87-94
- Bashamboo A, Bhatnagar S, Kaur A, Sarhadi VK, Singh JR and Ali S. (2003) Molecular characterization of Y-derived marker chromosome and identification of indels in the DYS1 region in a patient with stigmata of Turner Syndrome. Current Sci. 84 (2) : 219-249.
- Grover I.S, Kaur A, Mahajan RK, (1995). Mutagenicity of some dye effluents, Ind. Natl. Acad. Sci. 19 (7&8) : 149-158.
|
7 |
Dr. Badaruddoza |
- Badaruddoza and Afzal M (1993). Inbreeding depression and intelligence quotient among North Indian children. Behaviour Genetics 23: 343-347.
- Badaruddoza, Afzal M and Akhtaruzzaman (1994). Inbreeding and Congenital Heart Diseases in a North Indian Population. Clinical Genetics 45: 288-291.
- Badaruddoza (2004). Inbreeding effects on metrical phenotypes among North Indian Children. Collegicum Antropologicum 28(Suppl. 2): 311-318.
- Badaruddoza (2004). Effect of inbreeding on Wechsler intelligence test scores among North Indian Children. Asia Pacific Journal of Public Health 16(2): 99-103
- Badaruddoza and Punarjot Kaur (2010). Familial patterns of blood pressure with respect to anthropometric variables among Lobana (Nomadic origin) population in Punjab, India. Asia Pacific Journal of Public Health. DOI: 10.1177/1010539508372539.
|
8 |
Dr. Manpreet Kaur |
- Kaur, M., Singh, K., Rup, P.J., Kamboj, S.S., Singh, J. (2009) Anti-insect potential of lectins from Arisaema species towards Bactrocera cucurbitae. Journal of Environmental Biology 30(6), 1019-1023.
- Kaur, M., Singh, K., Rup, PJ., Kamboj, SS., Saxena, AK., Sharma, M., Bhagat, M., Sood, SK., Singh, J. (2006). A tuber lectin from Arisaema jacquemontii Blume with anti-insect and anti-proliferative properties. J. of Biochem and Mol Biol. 39: 432-440.
- Kaur, M., Singh, K., Rup, PJ., Saxena, AK., Khan, R., Tashfeen, A., Singh, S. and Singh, J. (2006). A tuber lectin from Arisaema helleborifolium Schott with anti-insect activity against Bactrocera cucurbitae (Coquillett) ant anti-cancer effect on human cancer cell lines. Arch Biochem Biophys. 442: 156-165.
- Kaur, N., Singh, J., Kambnoj, SS., Agrewala, JM., Kaur, M. (2005). Two novel lectins from Parkia biglandulosa and Parkia roxburghii: Isolation, physicochemical characterization, Mitogenicity and anti-proliferative activity. Protein and Peptide Lett. 12: 589-595.
- Kaur, M., Singh, J., Singh, S., Singh, J., Kaur, A., Sood, SK. and Saxena AK (2005). Isolation and Characterization of N-acetyl-D-lactosamine specific lectin from Arisaema intermedium Blume and Arisaema wallichianum Hook. F. Indian J Biochem Biophy. 42: 34-40.
|
9 |
Dr. Kamlesh Guleria |
- Roy, F.H., Singh, D., Guleria, K., Singh, R.S. (2005) Comprehensive Classification of Pediatric Cataracts. Ann Ophthalmol, 37(3):157-183.
- Guleria, K., Sperling, K., Singh, D., Varon, R., Singh, J.R., Vanita, V. (2007). A novel mutation in the connexin 46 (GJA3) gene associated with autosomal dominant congenital cataract in an Indian family. Mol. Vis. 13: 1657-1665.
- Guleria, K., Vanita, V., Singh, D., Singh, J.R. (2007). Novel “pearl box cataract” associated with mutation in the connexin 46 (GJA3) gene. Mol. Vis. 13: 797-803.
- Guleria, K. and Sambyal, V. (2010). Spectrum of Chromosomal Aberrations in Peripheral Blood Lymphocytes of Gastrointestinal Tract (GIT) and Breast Cancer Patients. Int. J. Hum. Genet. 10(1-3): 147-158.
- Saxena, R., Kohli, S., Guleria, K., Verma, I.C. (2010). Novel human pathological mutations. Human Genetics, 127: 463-490.
|
Ongoing Research Projects in the Department
Title
of the Project
|
PI/Co-I
|
FundingAgency
|
Amount (Rs.)
|
Period
|
Centre of Excellence in Sports Sciences
|
Dr. A.J.S. Bhanwer
Dr. Gursatej Gandhi
|
UGC
New Delhi
|
30.00 Lakhs
|
2007-2010
|
Analysis of Genetic determinants of T2DM
and their role in its susceptibility in some North-West Indian population
groups.
|
Dr. A.J.S. Bhanwer
Dr. Vasudha Sambyal
|
DBT
New Delhi
|
16.75 Lakhs
|
2008-2011
|
Molecular genetic analyses in diabetic retinopathy
cases
|
Dr. Vanita Kumar
|
DST, SERC Fast Track Scheme
|
18.96 Lakhs
|
2008-2011
|
Assessment of VEGF Polymorphisms and Serum Vascular Endothelial Growth Factor (sVEGF-C)
level as Prognostic Marker for Breast Cancer
|
Dr. Kamlesh Guleria,
Dr. Vasudha Sambyal
|
DBT
|
16.08 Lakhs
|
2009-2012
|
Study of Adiponectin Levels and Single Nucleotide
Polymorphisms in the Adiponectin Gene in Type 2 Diabetic Women
|
Dr. Kawaljit Kaur
Mentor:
Dr. A.J.S. Bhanwer
|
DST
(DST-WOS-A)
|
17.88
Lakhs
|
2009-2012
|
Molecular Studies of Alcoholism in SC Population of
Punjab
|
Dr. A.J.S. Bhanwer
|
UGC
|
11.72
Lakhs
|
2010-2013
|
Metabolic Genotypes as Modulators of DNA and
Chromosomal Damage in Persons Engaged in Quarrying/Stone Crushing
|
Dr Gursatej Gandhi
|
DST
|
18.80
Lakhs
|
2010-2013
|
Genetic polymorphism of MTHFR: Its implication as maternal risk factor for Down Syndrome
|
Dr. Anupam Kaur
|
UGC
|
8.61
Lakhs
|
2010-2013
|
|
